carvedilol+CR

__Oral dosage (extended-release carvedilol phosphate capsules; Coreg CR™):__ //Adults:// Initially, 20 mg PO once daily, administered in the morning with food. A lower starting dose of 10 mg PO once daily may be used and/or the rate of up‑titration may be slowed if clinically indicated (e.g., due to hypotension, bradycardia, or fluid retention). Prior to drug initiation, stabilize hemodynamics and minimize fluid retention. Dosage should be individualized and closely monitored by a physician during up-titration. After 3 to 10 days, the dosage may be increased to 40 mg PO once daily. If tolerated, then increase to the target dosage of 80 mg PO once daily. When converting from immediate-release carvedilol to Coreg CR™ capsules, clinicians may utilize the following dosage conversion information.[|[9861]] If taking carvedilol tablet dosage of 3.125 mg PO twice daily, may convert to Coreg CR™ 10 mg PO once daily. If taking carvedilol tablet dosage of 6.25 mg PO twice daily, may convert to Coreg CR™ 20 mg PO once daily. If taking carvedilol tablet dosage of 12.5 mg PO twice daily, may convert to Coreg CR™ 40 mg PO once daily. If taking carvedilol tablet dosage of 25 mg PO twice daily, may convert to Coreg CR™ 80 mg PO once daily.